Cannabinol, or CBN, is one of the most important active compounds found in the Cannabaceae family of plants. With recent research indicating it could be used for its sedative properties, as well as the ability to boost the efficacy of other cannabinoids, CBN is quickly becoming a focal point of researchers and innovators alike. Now, with premium Cannabinol extracts and distillates available from ECS Brands, the opportunity to incorporate it into new products has never been easier!
What Is Cannabinol and How Is It Made?
When it comes to its formation, cannabinol is one of the last molecular developments in the chain. CBN is a cannabinoid that forms primarily due to the decomposition (or oxygenation) of THC. To put it succinctly, with the application of heat:
- THCa becomes THC and THCV
- Then, when exposed to air, or decarboxylated, the THCa becomes CBNa
- The additional application of heat/UV light can convert this acid into CBN.
This chemical process (specifically the natural degradation due to oxidization) actually allows scientists to date a plant/sample based on the levels of CBN present. Moreover, as a constituent of THC, it exhibits some of the same properties.
How Does CBN Affect the Body?
Cannabinol acts on the cannabinoid receptors but also acts on targets outside of the endocannabinoid system, namely blocking TRP channels. TRP channels are found on the outside of cell membranes and control vision, pain, temperature, sedation, sleep and touch sensation. A few TRP channels are also responsible for other sensations like the ability to detect heat and cold. (1, 2)
CBN has been shown to have several useful properties, including sleep regulation. In a recent study, Steep Hill Laboratories concluded that 5 mg. of CBN was just as effective as 10mg. of diazepam at regulating certain aspects of brain function. Animal studies are now underway to test the applications of cannabinol on a variety of health benefits. (3)
Moreover, Cannabinol also regulates brain cell excitatory activity, having a calming effect by acting on CB2 (relaxation) receptors and minimally on CB1 (excitatory) receptors. (4)
Furthermore, cannabinol was found to stimulate bone marrow cell colony formation in 2007 by acting on CB2 receptors. (5)
In an early 1975 human trial, cannabinol and delta-9-tetrahydrocannabinol were compared in a 66-point test score regarding their effects on mental and psychological effects. The study authors concluded that “The volunteers reported feeling drugged, drunk, dizzy, and drowsy under the delta-9-THC condition, but not under the CBN condition”. (6)
Whilst this was an early study, it does potentiate that CBN may offer some of the positive effects of THC, such as appetite stimulation and sedation, without the side effects often associated with the cannabinoid.
CBN and Product Development- Potential Usecases
Although research is currently limited surrounding CBN, studies show it is a promising nutraceutical, regulating brain cell relaxation, supporting bone cell formation and acting on a variety of endocannabinoid and TRP receptors.
So, first and foremost, CBN may be useful in the development of natural sedatives and sleep products. As it has been shown to have similar effects to THC, without the side effects, it could also be useful as an alternative for people with sensitivity to the cannabinoid.
Second, by blocking some TRP channels, CBN may also be effective in reducing the body’s immune response associated with skin conditions, itch, and allergies. These anti-inflammatory properties have led to additional studies on the use of cannabinol in topical applications. After being shown to inhibit skin cell proliferation, Cannabinol may become a useful ingredient in topical applications, to treat skin conditions such as eczema and psoriasis.
Third, with the aforementioned anti-inflammatory potential, CBN may also become a natural ingredient for pain reduction and regulation. With similar properties to THC, without the typical ‘drowsiness’ that ensues, Cannabinol may become the go-to hemp extract for these types of products.
Of course, research is on-going, and as yet these hemp extracts have not been approved for consumption by the FDA.
However, a wide range of wholesale hemp extracts are available through ECS Brands, and we have a suite of product development tools at your disposal. To learn more about the potential of CBN, or how to integrate it into your own products reach out and connect with our team! email@example.com
About ECS Brands
ECS brands is a Colorado-based company delivering true full-spectrum hemp oils, extracts and distillates.
With a focus on whole-body health and a balanced lifestyle, ECS brands are simplifying research and education through its range of hemp-based products, targeting the body’s endocannabinoid system to help restore both neural and physical homeostasis.
Moreover, ECS brands promote entrepreneurship and product integration with a range of wholesale extracts, oils, and distillates. The company also oversees the operations of a number of hemp-based brands, including Hemp Fuel, Care By Derma, and Enlighten Hemp, to further drive the adoption of hemp-based products and holistic health.
1. Owsianik, Grzegorz; Voets, Thomas; Nilius, Bernd (2009-09-17), “Transient receptor potential channels”, Ion ChannelsFrom Structure to Function, Oxford University Press, pp. 511–537.
2. Gees, M, Colsoul, B, Nilius, B. The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling. Cold Spring Harb Perspect Biol. 2010 Oct; 2(10): a003962.
3. Cannabinol (CBN): A Sleeping Synergy. Sleep Hill Laboratories. 10-31-2017.
4. Musty, RE, Crippa, J. Potential therapeutic effects of cannabinoids on anxiety, a review. IACM 3rd Conference on Cannabinoids in Medicine. 2005, Leiden University.
5. Scutt, A, Williiamson, EM. Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int. 2007 Jan; 80 (1):50-9.
6. Kamiol, G, Shirakawa, I, et al. Effects of delta9-tetrahydrocannabinol and cannabinol in man. Pharmacology. 1975; 13 (6):502-12.